Abstract
3/β-Hydroxy-l 3α-amino-13,17-seco-5α-androstan-17-oic- 13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate was prepared by reacting 4-[p-[bis(2-chloroethyl)amino]phenyl]butyryl chloride hydrochloride with 3β-hydroxy-13α-amino-13,17-seco-5α-androstan- 17-oic-13,17-lactam. The cytostatic action of the ester was investigated on two tumor systems (B16 melanoma on C57 bl mice and T8-Guerin on rats).
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