Abstract
Two articles published in Science identified a new component of the circadian clock in the mammalian forebrain. NPAS2 (neuronal PAS domain 2 protein), a transcription factor highly homologous to the circadian factor CLOCK, was shown to possess functions similar to CLOCK in the regulation of the biological clock. In a companion paper, the same authors show that the DNA binding activity of the transcription complexes containing CLOCK or NPAS2 is modulated by the redox state of the NAD cofactor. These results raise the possibility that fluctuations in the intracellular redox state could influence biological rhythms. [Reick, M. et al. (2001) Science 293, 506–509; Rutter, J. et al. (2001) Science 293, 510–514] AB
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