Abstract
Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.
Highlights
The genus Arthrinium has wide geographic distribution and host range as plant pathogens, endophytes, saprobes, etc., while Poaceae and Cyperaceae are the major host plant families [1]. some Arthrinium species have been reported as phytopathogens [2,3,4], or even to cause cutaneous infections in humans [5], many others are known to produce diverse bioactive compounds with a variety of pharmacological applications
UJNMF0008 from deep-sea sediment gained our interest owing to its strong inhibitory activity
UJNMF0008 from deep-sea sediment gained our interest owing to its strong inhibitory activity against Staphylococcus led to to the the discovery discovery against aureus
Summary
The genus Arthrinium has wide geographic distribution and host range as plant pathogens, endophytes, saprobes, etc., while Poaceae and Cyperaceae are the major host plant families [1]. Cytotoxic cytochalasins, pyridone alkaloids and polyketides, along with naphthalene glycosides with COX-2 inhibitory activity, were obtained from the sponge-derived fungus A. arundinis ZSDS1-F3 [6,7,8,9]; arundifungin with antifungal property was isolated from another A. arundinis species [10]; griseofulvin derivatives showing lethality against the brine shrimp Artemia salina were reported from a gorgonian-derived. Apiospora montagnei [13]; and volatile compounds in endophytic Arthrinium sp. In addition to the of a series of pyridone alkaloids with antibacterial and cytotoxic activities [15]. Further of the remaining have resulted and structural characterization of an array of polyketide compounds, including five new in the isolation and structural characterization of an array of polyketide compounds, chromone including arthones. We we describe describe the the details details of of the the isolation, isolation, structure structure elucidation, elucidation, and and biological biological evaluations evaluations of of compounds 1–13
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