Abstract
A simple, specific, precise, sensitive and rapid reverse phase-HPLC method was developed for determination of ketorolac enantiomers, a potent nonnarcotic analgesic in pharmaceutical formulations. The method was developed on a chiral AGP column. Mobile phase was 0.1M sodium phosphate buffer (pH 4.5): Isopropanol (98:2, v/v), at a flow rate of 1mL/min with run time of 15min. Ultraviolet detection was made at 322nm. The linearity range was 0.02–10μg/mL for each of the enantiomers. The mobile phase composition was systematically studied to find the optimum chromatographic conditions. Validation of the method under the conditions selected showed that it was selective and precise and that the detector response was linear function of ketorolac.
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