Abstract
The primary focus of this work is the synthesis of the new P,N-ligand class 4. Its utility was demonstrated through the asymmetric hydrogenation of acyclic imines. Although both diastereomers of ligands 4 and 5 can be prepared, the α-diastereomers (shown) gave better selectivity. Importantly, iridium complex 6 selectively reduced the imine precursor to 8 and left the pendant ketone untouched. Chiral pyrrolidinones and piperidinones can be prepared with this method. The cyclization occurs spontaneoulsy under the mild deprotection conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have