Abstract
Next-generation sequencing (NGS) has made analyzing DNA faster and cheaper, with effects felt in the lab, clinic, and beyond. A set of newly launched technologies is offering a twist on the chemistry behind the process. Experts say these efforts may signal the first big change to NGS in years. NGS relies on sequencing by synthesis: the sequence of a template DNA strand is determined by synthesizing a complementary strand from fluorescently labeled bases. After each base is incorporated by a polymerase and is imaged, its fluorescent tag is removed and another base can be added. Now, companies are introducing sequencing platforms that separate fluorescent labeling from the extension of the complementary DNA strand, touting improvements in accuracy that result from optimizing each step. Late in May, Element Biosciences published on the chemistry behind its platform for avidity sequencing ( Nat. Biotechnol. 2023, doi: 10.1038/s41587-023-01750-7 ). Biochemists define avidity as the
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
