Year-end Sale % OFF 
Abstract
BackgroundA variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using wild-derived dominant resistant Mus spretus mice, and one has been confirmed as a low penetrance cancer susceptibility gene in a variety of human cancers.ResultsIn the present study, we found that wild-derived PWK mice developed no tumour by treatment with the two-stage skin carcinogenesis protocol. This phenotype is dominant resistant when crossed with the highly susceptible strain FVB. By analyzing the F1 backcross generation between PWK and FVB, we found empirical evidence of significant linkage at the new loci Skts-fp1 on chromosome 4 and suggestive linkage on chromosomes 1, 3, 11, 12 and 14 for skin tumour susceptibility. Skts-fp1 includes the Skts7 interval, which was previously mapped by a Mus spretus and NIH backcross. We also observed suggestive linkage on chromosomes 1 and 2 in the female population only, while suggestive linkage on chromosomes 14 and 15 only was observed in the male population. A significant genetic interaction was seen between markers of D11Mit339 and D16Mit14.ConclusionAnalysis of this new cross may facilitate the identification of genes responsible for mouse skin cancer susceptibility and may reveal their biological interactions.
Highlights
A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development
The susceptibility for the two-stage skin carcinogenesis model varies among mouse strains [6,7], and the genetic approach has been performed to identify genes related to cancer susceptibility [8,9,10,11]
Since functional polymorphisms of AURKA were repeatedly reported to be determinants of individual risk for colon, esophageal, skin, lung, breast, ovarian, and prostate cancers in the human population [16,17,18,19], identification of genetic components in the mouse skin cancer susceptibility could facilitate the identification of candidate cancer risk factors in the human population
Summary
A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Analysis of the human population is useful in finding the gene related to high penetrance disease, the identification of low penetrance tumour susceptible genes is still difficult. This is mainly due to heterogeneous genetic background and complex environmental effects. The susceptibility for the two-stage skin carcinogenesis model varies among mouse strains [6,7], and the genetic approach has been performed to identify genes related to cancer susceptibility [8,9,10,11]. Since functional polymorphisms of AURKA were repeatedly reported to be determinants of individual risk for colon, esophageal, skin, lung, breast, ovarian, and prostate cancers in the human population [16,17,18,19], identification of genetic components in the mouse skin cancer susceptibility could facilitate the identification of candidate cancer risk factors in the human population
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
