Abstract
The selective C-S bond cleavage of a β-sultam ring was achieved using EtAlCl2 as a Lewis acid. Furthermore, treatment of 4-silyl-β -sultams with EtAlCl2 effected the selective C-N bond cleavage which, followed by desilylation, afforded (E)-vinylsulfonamides stereospecifically. The Pummerer reaction of 4-sulfenyl- β -sultams produced α-amino acid thioesters, and the chiral α-amino acid thioesters were prepared from chiral imines and methanesulfonyl chloride.
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