Abstract
In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2′-deoxyuridine (2) and 3-phenylethyl-2′-deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds 1–5 showed variable cytotoxic activity against three cancer cell lines.
Highlights
Nucleosides and cerebrosides are found in both terrestrial and marine organisms
Sea cyanobactrium Moorea producens revealed the presence of nitrogen-containing compounds, polyketides and peptides
In continuation of our ongoing interest to allocate new bioactive compounds from Red Sea marineof the cyanobacterium. In this we reported and structure determination cyanobacteria
Summary
Nucleosides and cerebrosides are found in both terrestrial and marine organisms. Cerebrosides are composed of a hydrophobic part named ceramide, which is linked to one sugar moiety [1]. Cerebrosides play an important role in major cellular processes including growth, morphogenesis and cell differentiation. Previous work on the Red. Sea cyanobactrium Moorea producens revealed the presence of nitrogen-containing compounds, polyketides and peptides [16,17]. Moorea producens revealed the presence of nitrogen-containing compounds, polyketides andnew peptides compounds from. In continuation of our ongoing interest to allocate new bioactive compounds from Red Sea marineof the cyanobacterium. In this we reported and structure determination cyanobacteria [16,17,18,19], we here focus onpaper, the Red. In thiscerebroside, paper, we reported the isolation structure determination of a new cerebroside, of a new mooreaside.
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