Abstract
OPINION article Front. Neurol., 15 September 2015Sec. Stroke Volume 6 - 2015 | https://doi.org/10.3389/fneur.2015.00203
Highlights
Intravenous thrombolytic therapy in acute ischemic stroke patients is complicated by intracerebral hemorrhage (ICH) at a site remote from the infarcted area in roughly 2–3% of cases [1, 2]
Cerebral microbleeds (CMBs) are markers of bleeding-prone microangiopathies – most commonly hypertensive arteriopathy and cerebral amyloid angiopathy (CAA) [4] – that are visualized on T2*-weighted magnetic resonance imaging (MRI)
It is biologically plausible that thrombolysis-induced expansion of rapidly appearing CMBs might be the cause underlying a proportion of remote intracerebral hemorrhage (rICH) in acute ischemic stroke patients
Summary
Intravenous thrombolytic therapy in acute ischemic stroke patients is complicated by intracerebral hemorrhage (ICH) at a site remote from the infarcted area in roughly 2–3% of cases [1, 2]. Radiographic studies have demonstrated development of new CMBs in 5–13% of acute ischemic stroke patients within the first week after symptom onset [6,7,8].
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