Abstract
Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL.
Highlights
IntroductionVarious natural products, distributed mainly in marine soft corals of the genus Lobophytum (Alcyoniidae) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21], have attracted much attention from chemists specializing in natural products due to their structural complexity and remarkable pharmacological activities such as cytotoxicity [2,3,4,5,6,7,8,9], antibacterial activities [10], anti-inflammatory properties [10,11,12], and HIV-inhibitory activity [13]
The concentrated residue was subjected to column chromatography and high-performance liquid chromatography (HPLC), leading to the purification of 1–5
The planar structure of durumolide M, possessing an α-methoxymethyl-γ-lactone ring fused to a 14-membered ring at C-1 and C-14, was, with certainty, assigned as 1
Summary
Various natural products, distributed mainly in marine soft corals of the genus Lobophytum (Alcyoniidae) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21], have attracted much attention from chemists specializing in natural products due to their structural complexity and remarkable pharmacological activities such as cytotoxicity [2,3,4,5,6,7,8,9], antibacterial activities [10], anti-inflammatory properties [10,11,12], and HIV-inhibitory activity [13]. Durumolides M–Q were evaluated in vitro for the cytotoxicity against A-459 (human lung adenocarcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines, and antiviral activity against human cytomegalovirus
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