Abstract
Tumor Immunotherapy An adoptive cellular therapy that expands clonal T cells could help fight deadly heterogeneous brain tumors, medulloblastoma, and glioblastoma. Working in mice, Flores et al. used dendritic cells expressing tumor RNA to expand polyclonal T cells that quickly react against a variety of different antigens within different brain tumors. Promising results were also obtained in a patient with recurrent medulloblastoma. Although previous adoptive T cell therapies have proven effective against several advanced cancers, the current method could provide patients with effective T cell therapy for brain tumors. Sci. Adv. 10.1126/sciadv.aav9879 (2019).
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