Abstract
A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
Highlights
Marine organisms are the amazing source of secondary metabolites due to the biodiversity of the oceans
Okinawan marine organisms [3,4,5,6,7], we examined a soft coral, Lobophytum sp., subsequently isolating a novel casbane 1 and two new cembranes 2, 3, along with four known cembrane diterpenoids 4–7 (Figure 1) [8,9,10,11]
Escherichia coli withatinhibition zones at μg/disc, 18 and 15 mm at 50Repeated μg/disc, bacterium Escherichia coli with inhibition zones
Summary
Marine organisms are the amazing source of secondary metabolites due to the biodiversity of the oceans. Most of the casbane-type diterpenoids are two ring-based macrocyclic structures where the junction of the two rings is cis-fused [10,13,14] and few molecules showed trans junctions [15]. These types of metabolites are of considerable pharmacological interest due to their unique structures and exhibit potential bioactivities, including cytotoxicity [16,17,18,19,20,21,22,23], anti-viral [23], anti-inflammatory [24,25,26] and antimicrobial activities [24]; casbane diterpenoids display anti-proliferative activity [10].
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