Abstract
Both epidermal growth factor (EGF) and transforming growth factor type-beta1 (TGF-beta1) have positive and negative growth effects on cell growth. In this review, signal transduction of EGF and TGF-beta1 from their receptor to cell cycle or apoptosis is reviewed and discussed. New evidence that high concentration of EGF induces apoptosis in breast and esophageal cancer in vivo is reported. p53 and RB gene is emphasized as a key gene in induction of cell cycle progression and apoptosis. This review indicates that apoptosis based therapy by EGF and TGF-beta1 is a useful cancer strategy.
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