Abstract
Adult male rats reared on a standard diet were treated with peroral dosages of 1 alpha-hydroxyvitamin D3 (1 alpha-OHD3). A rapid effect on the serum calcium level was found; the elevation (compared to untreated controls) occurred as early as two weeks and remained elevated throughout the treatment period. Histomorphometric analysis revealed a decreased resorption rate and increased incorporation of tetracycline after four weeks of 1 alpha-OHD3 treatment. These results were associated with a significant increase of cortical as well as trabecular bone, as well as increased levels of bone hydroxyproline and hexosamines. A clearly significant decrease in the total volume of parathyroids was found after six weeks; this was accompanied by a slight pycnosis of the chief cells, which may account for reduced parathyroid activity.
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