Abstract
A series of 1-(4-biphenylyl)-2-phenylethylamin derivatives was synthesized as potential antispasmodic and cardiovascular agents related to papaverine. Preliminary pharmacological tests, on isolated guinea pig ileum and anesthetized cat blood pressure, showed that the new compounds possess nonspecific inhibitory action on smooth muscles. Keywords Biphenyl derivatives, various—synthesized, evaluated for antispasmodic and cardiovascular activity; 2-Phenylethylamines, subst ituted—synthesized, evaluated for antispasmodic and cardiovascular Activity; Antispasmodic activity—various substituted 1-(4-biphenylyl)-2-phenylethylamines evaluated; Cardiovascular activity—various substituted 1-(4-biphenyly1)-2-phenylethylamines evaluated; Structure-activity relationships—varioussubstituted 1-(4-biphenylyl)-2-phenylethylamines evaluated for antispasmodic and cardiovascular activity
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