Abstract
Nerve wrapping improves neurorrhaphy outcomes in case of peripheral nerve injuries (PNIs). The aim of this preclinical study was to assess the efficacy of two novel biodegradable wraps made of a synthetic 1% oxidized polyvinyl alcohol (OxPVA) and a natural leukocyte-fibrin-platelet membrane (LFPm) versus the commercial product NeuraWrap. After rats sciatic nerve transection and neurorrhaphy, the wraps were implanted and compared for functional outcome, by sciatic function index assessment; structural characteristics, by histological/immunohistochemical analysis; ultrastructural features, by transmission electron microscopy. Moreover, a morphometric study was also performed and collagen distribution was observed by Second Harmonic Generation microscopy. After 12 weeks from implantation, all wraps assured nerve function recovery; no scar tissue/neuromas were visible at dissection. LFPm wraps were completely resorbed, while residues of OxPVA and NeuraWrap were observed. In all groups, biocompatibility was confirmed by the absence of significant inflammatory infiltrate. According to histological/immunohistochemical analysis and morphometric findings, OxPVA and LFPm wraps were both effective in preserving nerve integrity. These results assess that bioengineered OxPVA and LFPm wraps successfully guarantee favorable lesion recovery after PNI/neurorrhaphy and, in future, may be considered an interesting alternative to the commercial NeuraWrap.
Highlights
Nerve wrapping improves neurorrhaphy outcomes in case of peripheral nerve injuries (PNIs)
Our attention focused on a novel biomaterial we developed that is 1% Oxdized Polyvinyl Alcohol (OxPVA)[22], which demonstrated a promising in vitro[23] and in vivo[24] outcome when used as nerve-conduit
The wraps based on oxidized polyvinyl alcohol (OxPVA) and leukocyte-fibrin-platelet membrane (LFPm) both proved to sustain peripheral nerve regeneration/repair after sharp transection as showed by structural, ultrastructural and morphometric approaches
Summary
Nerve wrapping improves neurorrhaphy outcomes in case of peripheral nerve injuries (PNIs) The aim of this preclinical study was to assess the efficacy of two novel biodegradable wraps made of a synthetic 1% oxidized polyvinyl alcohol (OxPVA) and a natural leukocyte-fibrin-platelet membrane (LFPm) versus the commercial product NeuraWrap. According to histological/immunohistochemical analysis and morphometric findings, OxPVA and LFPm wraps were both effective in preserving nerve integrity These results assess that bioengineered OxPVA and LFPm wraps successfully guarantee favorable lesion recovery after PNI/neurorrhaphy and, in future, may be considered an interesting alternative to the commercial NeuraWrap. The wraps consisted of a leukocyte-fibrin-platelet membrane (LFPm)[25,26] and OxPVA22 Their potential in promoting an optimal recovery of the lesion was compared with that of the collagen-based commercial product of bovine origin NeuraWrap (Integra LifeSciences, Plainsboro, NJ) (i.e. control group). Verifying the behavior of the LFPm and OxPVA with respect to NeuraWrap may be interesting as both LFPm and OxPVA could be encountered as potentially less expensive alternatives than the commercial counterpart
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
