New Biocompatible Mesoporous Silica/Polysaccharide Hybrid Materials as Possible Drug Delivery Systems.

Andreea Madalina Pandele,Adi Ghebaur,Horia Iovu,Sorina Alexandra Garea,Corina Andronescu

doi:10.3390/ma12010015

Andreea Madalina Pandele, Adi Ghebaur + Show 3 more

Open Access

https://doi.org/10.3390/ma12010015

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Journal: Materials	Publication Date: Dec 20, 2018
Citations: 15	License type: CC BY 4.0

Affiliation: Academy of Romanian Scientists, Ruhr University Bochum

Abstract

A high number of studies support the use of mesoporous silica nanoparticles (MSN) as carriers for drug delivery systems due to its high biocompatibility both in vitro and in vivo, its large surface area, controlled pore size and, more than this, its good excretion capacity from the body. In this work we attempt to establish the optimal encapsulation parameters of benzalkonium chloride (BZC) into MSN and further study its drug release. The influence of different parameters towards the drug loading in MSN such as pH, contact time and temperature were considered. The adsorption mechanism of the drug has been determined by using the equilibrium data. The modification process was proved using several methods such as Fourier transform-infrared (FT-IR), ultraviolet-visible (UV-VIS), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Since MSN shows a lower drug release amount due to the agglomeration tendency, in order to increase MSN dispersion and drug release amount from MSN, two common biocompatible and biodegradable polymers were used as polymer matrix in which the MSN-BZC can be dispersed. The drug release profile of the MSN-BZC and of the synthesized hybrid materials were studied both in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymer-MSN-BZC hybrid materials exhibit a higher drug release percent than the pure MSN-BZC when a higher dispersion is achieved. The dispersion of MSN into the hybrid materials was pointed out in scanning electron microscope (SEM) images. The release mechanism was determined using four mathematic models including first-order, Higuchi, Korsmeyer–Peppas and Weibull.

Highlights

In recent years, drug delivery systems have been rapidly developed and become an important field in medical applications [1,2]
The successful modification of mesoporous silica nanoparticles (MSN) with different amounts of benzalkonium chloride (BZC) was proved by Fourier transform-infrared (FT-IR) spectra in which distinctive bands assigned to BZC structure into the MSN-BZC spectra were identified, as well from the Thermogravimetric analysis (TGA) data where a significant mass loss is obtained for MSN-BZC compared with pure MSN
The pH value of the environment, the contact time or the temperature used during the adsorption experiments proved to be important factors in the encapsulation process of BZC into the MSN

Summary

Introduction

Drug delivery systems have been rapidly developed and become an important field in medical applications [1,2]. MSN exhibit a higher resistance to temperature and pH variation, mechanical stress and hydrolysis-induced degradations making a stable and rigid framework. Another important advantage of MSN for the medical field is their degradability in aqueous solution which can avoid further problems related to the removal of the material after use, being excreted from the body. Since for the medical field it is very important to control the pore size, geometry and shape of the carrier, in the case of MSN the size and the surface chemistry of the pore could be controlled and changed depending on the drug which should be encapsulated to obtain the proper loading and release of the drug. MSN proved to exhibit a higher versatility compared with other systems like polymer nanoparticles and liposomes

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Discussion

Conclusion