Abstract
AbstractTurkey has a very rich flora and a long history of herbal medicine practices. The biological evaluation of substances from plant sources is highly relevant for the identification of lead compounds which can result in the development of novel and safe medicinal agents. During our extensive studies with Turkish medicinal plants, we have isolated and characterized a large number of natural products. Although Turkey is endowed with a wide variety of medicinal plants, very little effort has been made so far towards bioassay‐directed isolation of biologically active compounds from indigenous plants. During the past few years, we have also been engaged in the isolation and structure elucidation of compounds through a bioassay‐directed fractionation procedure.In this manuscript, new bioactive steroidal alkaloids isolated from Buxus, Veratrum and Fritillaria species are presented. Among these, four steroidal alkaloids isolated from the leaves of Buxus longifolia have shown significant antibacterial activity against Salmonella typhi, Shigella flexneri, Escherichia coli and Pseudomonas aeruginosa. Three steroidal alkaloids from Veratrum album have been shown to have antihypertensive actions. In addition, a new steroidal base obtained from the bulbs of Fritillaria imperialis exhibited anticholinergic activity as manifested by the blockade of acetylcholine responses on isolated guinea‐pig ileum and atria.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
