Abstract
Ten flavonoid glycosides, apetalumosides A (1), B1–B7 (2–8), and C (9), quercetin 3-O-(2,6-di-O-β-d-glucopyranosyl)-β-d-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1–9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1–3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure–activity relationship study revealed that 7-hydroxyl group is an essential moiety.
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