New benzoyl acetohyrazone based metal complexes with Viral DNA binding and cleavage and antimicrobial treatments: Synthesis and biological activities

Abstract

Some transition metal ions as Co(II), Ni(II), Cu(II) and Zn(II) form complexes with Benzoyl Acetohyrazone ligand, (1) [HL] was synthesized and characterized using physical and spectroscopic methods. Analytical data showed that the complexes found in (1:1) ligand: metal ratio. Spectral studies revealed that the ligand bonded to the metal ion in neutral bidentate or monobasic bidentate manner through azomethine nitrogen atom, protonated/deprotonated hydroxyl group. From the electronic spectral data together with magnetic susceptibility values a distorted octahedral geometry can be proposed for all complexes except complexes (4, 9, 13) which have square planar structure. Electron spin resonance spectra for Cu(II) complex (2) revealed axial symmetry with g|| >g⊥>ge, indicating distorted octahedral or square planar geometries and the unpaired electron exists in a d(x2−y2) orbital with marked covalent bond feature. The synthesized complexes presented good to excellent antimicrobial activity, and the most active complexes against Aspergillus niger were (5, 10, 14) with inhibition zone of 20, 23 and 25 mm, respectively. Complex (2) showed interesting activity against Escherichia coli with inhibition zone value 18.2 mm. Gel electrophoresis experiments using viral B- DNA were performed with the ligand and its complexes and show great effect in viral B cleavage.