New Benthic Cyanobacteria from Guadeloupe Mangroves as Producers of Antimicrobials.

Sébastien Duperron,Sylvain Durand,Mehdi A Beniddir,Olivier Gros,Marie-Lise Bourguet-Kondracki,Charlotte Duval,Arlette Longeon,Cécile Bernard

doi:10.3390/md18010016

Abstract

Benthic cyanobacteria strains from Guadeloupe have been investigated for the first time by combining phylogenetic, chemical and biological studies in order to better understand the taxonomic and chemical diversity as well as the biological activities of these cyanobacteria through the effect of their specialized metabolites. Therefore, in addition to the construction of the phylogenetic tree, indicating the presence of 12 potentially new species, an LC-MS/MS data analysis workflow was applied to provide an overview on chemical diversity of 20 cyanobacterial extracts, which was linked to antimicrobial activities evaluation against human pathogenic and ichtyopathogenic environmental strains.

Highlights

Cyanobacteria are among the important primary producers in various coastal ecosystems including mangroves
2020, 18, smaller of16this diversity, with over 50% of characterized metabolites reported from the order. We investigated both the phylogenetic and chemical diversity of cultivable. We investigated both the phylogenetic and chemical diversity of cultivable cyanobacteria isolated from coastal habitats in Guadeloupe (French West Indies)
20 cyanobacterial strains were namely successfully isolated, andlagoon grownclose fromtogreen biofilms collected from locations in Guadeloupe, the Manche-à-Eau red mangrove collected from distinct locations in Guadeloupe, namely the Manche-à-Eau lagoon close to red trees, the Marina Bas-du-Fort, mangrove treesDes

Summary

Introduction

Cyanobacteria are among the important primary producers in various coastal ecosystems including mangroves. Cyanobacteria are of particular interest as ecologically-relevant microorganisms, they are regarded as producers of a broad diversity of bioactive secondary metabolites including cyanotoxins and various antimicrobial compounds which influence their interactions with other organisms [1,4,5]. Some of these compounds are of pharmacological interest, as illustrated by the use of Brentuxymab vedotin, based on dolastatin 10 from Symploca, in the treatment of Hodgkin’s lymphoma [1,6]

Methods

Results

Conclusion