Abstract
Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.
Highlights
Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might serve as useful leads in the development of new pharmaceutical agents
Based on the fact that some of the bioactive materials isolated from marine animals have been produced by bacteria, we have focused our attention on new antitumor agents from microorganisms separated from marine organisms [1,2,3,4,5]
As part of this endeavor, we have conducted a search for antitumor compounds from a strain of Chaetomium globosum OUPS-T106B-6 that was originally isolated from the marine fish
Summary
Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might serve as useful leads in the development of new pharmaceutical agents. Our continuing search for cytotoxic metabolites from this fungal strain yielded two new azaphilones designated as seco-chaetomugilins A (3) and D (4) (Figure 1). The AcOEt extract of the culture filtrate was purified by bioassay-directed fractionation (cytotoxicities against P388 cell line) employing a stepwise combination of Sephadex LH-20, silica gel column chromatography, and reversed-phase HPLC (RP-HPLC) to afford seco-chaetomugilins A (3)
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