New Association Between Diabetes Mellitus and Pancreatic Cancer.

Abstract

Diabetes mellitus is a global issue which has affected the life of many people all over the world. This disorder which is also called the mother of all diseases possesses high pathogenicity and results in the emergence of many disorders. One of the known correlated diseases is pancreatic cancer which can be accompanied by diabetes mellitus. Therefor finding the new association between these diseases and on common genes is urgent. In this study, in order to survey this relationship between diabetes mellitus and pancreatic cancer, the common genes of these disorders were analyzed by bioinformatics tools. For this purpose, we screened 17 shared genes from microarray data downloaded from the Gene Expression Omnibus (GEO) database. In addition, the relationship between identified genes was constructed by STRING and DAVID tools. In total, 112 genes were identified to be differentially expressed. Among these, 17 genes were in common, including two genes that were down-regulated and others that were up-regulated. Other analyses showed that most of the genes were enriched in Vibrio cholera infection and the mTOR signaling pathway. The biological processes of such genes include oxygen and gas transport, phagosome acidification, and GTPase activity. In this study, 17 genes of common genes that had not previously been considered in diabetes and pancreatic cancer were screened, which can be further considered in clinical approaches and in vitro studies.