Abstract
Bacterial ribosomes consist of 50–60 proteins and three (5S, 16S, and 23S) rRNA molecules. Now that the determination of the primary structure of all the ribosomal components from Escherichia coli is complete (for reviews, see Noller 1980; Giri et al. 1984), current research is concentrating on regulation of the biosynthesis of ribosomal components, the architecture of the ribosome, principles of the ribosomal assembly and functions, and the evolutionary relatedness between components of the translational apparatus derived from various organisms. In this paper, we survey some of our recent contributions, with particular emphasis on the ribosomal elongation cycle.
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