Abstract
Organ fibrogenesis is characterized by a common pathophysiological final pathway independent of the underlying progressive disease of the respective organ. This makes it particularly suitable as a therapeutic target. The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” (referred to as SFB/TRR57) was hosted from 2009 to 2021 by the Medical Faculties of RWTH Aachen University and the University of Bonn. This consortium had the ultimate goal of discovering new common but also different fibrosis pathways in the liver and kidneys. It finally successfully identified new mechanisms and established novel therapeutic approaches to interfere with hepatic and renal fibrosis. This review covers the consortium's key kidney-related findings, where three overarching questions were addressed: (i) What are new relevant mechanisms and signaling pathways triggering renal fibrosis? (ii) What are new immunological mechanisms, cells and molecules that contribute to renal fibrosis?, and finally (iii) How can renal fibrosis be modulated?
Highlights
Frontiers in MedicineOrgan fibrogenesis is characterized by a common pathophysiological final pathway independent of the underlying progressive disease of the respective organ
Epidemiological studies show that chronic kidney disease (CKD) affects more than 10% of the world’s population [1]
A minor matrix production in proximal tubule epithelium could be detected, the proof of a contribution of proximal tubule epithelial cells to the pool of myofibroblasts failed in an inducible genetic fate tracing experiment using bigenic SLC34a1-GFPCreER;tdTomato mice in the murine kidney fibrosis model of ureteral obstruction (UUO) [14] as well as in the scRNA-seq study [17]
Summary
Organ fibrogenesis is characterized by a common pathophysiological final pathway independent of the underlying progressive disease of the respective organ This makes it suitable as a therapeutic target. The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” (referred to as SFB/TRR57) was hosted from 2009 to 2021 by the Medical Faculties of RWTH Aachen University and the University of Bonn. This consortium had the ultimate goal of discovering new common and different fibrosis pathways in the liver and kidneys.
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