Abstract
In Escherichia coli B, nucleic acid and protein syntheses were inhibited in the presence of chlorpromazine, promethazine, 2-chlorophenothiazine and librium. The presence of the dimethylaminoalkyl side chain of chorpromazine is essential for potent inhibition of these macromolecular syntheses. In parallel with the inhibition of protein synthesis, the processes of de-repression of alkaline phosphatase and induction of β-galactosidase were also inhibited in the presence of chlorpromazine and librium. We have found that all of the effects of these drugs on protein and nucleic acid syntheses in E. coli B are not due to an increased destruction of ATP in the drug-treated cultures. The interference with protein and nucleic acid syntheses may be due to the interaction of these drugs and deoxyribonucleic acid (DNA). Chlorpromazine is found to be effective in displacing methyl green (MG) from its complex with DNA and form insoluble complex with DNA.
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