New approaches to treating diabetic peripheral polyneuropathy in children and adolescents

Abstract

А hundred and seven patients (56 males and 51 females) aged 8 to 21 years who had suclinical and mild diabetic peripheral polyneuropathy received pathogenetic treatment. Thirty-nine patients took a combined drug including benfotiamine and pyridoxine in a daily dose of 300 mg for 6 weeks. Twenty-three and 45 patients were given a-lipoic acid in a daily dose of 10-15 mg/kg body weight for 8 and 12 weeks, respectively. The treatment was monitored by using the Total Symptoms Score and the Neuropathy Impairment Score for the Lower Extremities, stimulation electromyography of two nerves of the leg. The therapy showed significant positive changes in subjective and objective neurological symptoms and baseline altered indices, a good tolerability of all the drugs. The findings allow one to consider a-lipoic acid and "millegamma " as tablets to be an agent for the treatment of subclinical and mild forms of diabetic peripheral polyneuropathy.