Abstract
Atopic dermatitis (AD) takes special place in the structure of allergic diseases as it is one of the most prevalent and very first allergic manifestation, it often transforms into other allergic forms, decreases children’s life quality independent of the age and also needs long term and staged treatment. Purpose of work is to establish the status of immune status parameters and mediators of allergic inflammation and to assess the diagnostic capabilities of dermatoscopy and ultrasound examination of the skin in children with atopic dermatitis. Parameters of cellular and humoral immunnity, cytokine status, inflammatory mediators, morphological features of skin changes according to results of dermatoscopy and ultrasound examination were investigated in 128 children with atopic dermatitis aged from 1 to 18 years. Assessment of clinical course’s severity of atopic dermatitis was conducted by semiquantitative method using SCORAD index. In this article presents the results of immunological examination in children with AD and in healthy children aged from 1 to 18 years. Changes of parameters of cellular, humoral immunity, cytokine status and serum immunoglobulins dependent on severity of clinical course were found in children with atopic dermatitis. Atopic dermatitis is a chronic disease with very polymorphic manifestations in skin. According to the results we can conclude about presence of several dermatoscopy variants of skin damage on background of atopic dermatitis. In the study of echograms of skin areas affected by atopic dermatitis was noted thickening of all layers of skin, presence of hypoechoic wide band between the epidermis and the derma, diffuse decrease of derma echogenicity. Immunogram, dermatoscopy and ultrasound diagnostic of skin can be used in diagnostic process for verification and clarification of clinical diagnosis, evaluating of treatment effectiveness and examination of medical services quality.
Highlights
В структуре аллергических заболеваний особое место занимает атопический дерматит, который часто в дальнейшем трансформируется в другие формы аллергии, существенно снижает качество жизни детей, требует длительного и этапного лечения
Atopic dermatitis (AD) takes special place in the structure of allergic diseases as it is one of the most prevalent and very first allergic manifestation, it often transforms into other allergic forms, decreases children’s life quality independent of the age and needs long term and staged treatment
Purpose of work is to establish the status of immune status parameters and mediators of allergic inflammation and to assess the diagnostic capabilities of dermatoscopy and ultrasound examination of the skin in children with atopic dermatitis
Summary
Цель работы: установить состояние показателей иммунного статуса и медиаторов аллергического воспаления и оценить диагностические возможности дерматоскопии и ультразвукового исследования (УЗИ) кожи у детей с атопическим дерматитом. Исследовали показатели клеточного и гуморального иммунитета, цитокиновый статус и медиаторы воспаления, морфологические особенности изменений кожи по данным результатов дерматоскопии и ультразвукового исследования у 128 детей в возрасте от 1 года до 18 лет, страдающих атопическим дерматитом. У детей с атопическим дерматитом были выявлены изменения показателей клеточного и гуморального иммунитета, цитокинового статуса и сывороточных иммуноглобулинов, которые зависели от степени тяжести клинического течения заболевания. Parameters of cellular and humoral immunnity, cytokine status, inflammatory mediators, morphological features of skin changes according to results of dermatoscopy and ultrasound examination were investigated in 128 children with atopic dermatitis aged from 1 to 18 years.
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