Abstract
The pathogenesis of the development of drug-induced disorders while taking antipsychotic drugs is not well understood. The aim of the work is to study polymorphic variants of the multidrug resistance protein gene and genes encoding the metabolism and synthesis of dopamine and serotonin enzymes in antipsychotic-induced hyperprolactinemia in schizophrenia patients. As a result of a comprehensive study of 446 patients with schizophrenia and genotyping of 25 polymorphic variants of the MDR1, COMT, MAO-A, MAO-B, TPH1 and TPH2 genes, associations of polymorphisms rs1045642, rs2032582, rs4148739 (MDR1), rs6323 (MAO-А), rs1799836 (MAO-B) were revealed with the development of hyperprolactinemia. Further research is needed to develop personalized approaches to therapy.
Highlights
Выявлены ассоциации между наличием нейролептической гиперпролактинемии у пациентов и полиморфными вариантами гена MDR1 с использованием логистического регрессионного анализа с учетом нескольких ковариат (возраст, пол, длительность заболевания, курение, ведущая симптоматика и доза антипсихотиков в хлорпромазиновом эквиваленте)
При ассоциативном анализе полиморфных вариантов генов ферментов метаболизма и синтеза дофамина и серотонина выявлены ассоциации полиморфного варианта rs6323 гена МАО-А с ГП у мужчин и rs1799836 гена MAO-B с развитием ГП как у мужчин, так и женщин
Работа выполнена при поддержке гранта РФФИ No17-29-06035 «Новые подходы к фармакогенетике антипсихотикиндуцированной гиперпролактинемии у больных шизофренией»
Summary
The aim of the work is to study polymorphic variants of the multidrug resistance protein gene and genes encoding the metabolism and synthesis of dopamine and serotonin enzymes in antipsychotic-induced hyperprolactinemia in schizophrenia patients. As a result of a comprehensive study of 446 patients with schizophrenia and genotyping of 25 polymorphic variants of the MDR1, COMT, MAO-A, MAO-B, TPH1 and TPH2 genes, associations of polymorphisms rs1045642, rs2032582, rs4148739 (MDR1), rs6323 (MAO-А), rs1799836 (MAO-B) were revealed with the development of hyperprolactinemia.
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