Abstract
The receptor tyrosine kinase genes (NTRK1, 2, 3) are proto-oncogenes that are found in various solid tumors in children and adults. Currently, next-generation sequencing (NGS) is the preferred platform for detecting NTRK gene translocations. The scientific literature presents data on the effectiveness of entrectinib in patients with translocation of the NTRK, ROS1 and ALK genes, regardless of the partner gene. In the future, entreсtinib therapy can become an alternative to chemotherapy or can be used in combination or complex treatment of both primary malignant neoplasms and in the case of refractory, unresectable and recurrent forms of the disease.
Highlights
Для цитирования: Сулейманова А.М., Сагоян Г.Б., Киргизов К.И
The receptor tyrosine kinase genes (NTRK1, 2, 3) are proto-oncogenes that are found in various solid tumors in children and adults
Drilon A., Siena S., Ou S.I., Patel M., Ahn M.J., Lee J., Bauer T.M., Farago A.F., Wheler J.J., Liu S.V., Doebele R., Giannetta L., Cerea G., Marrapese G., Schirru M., Amatu A., Bencardino K., Palmeri L., Sartore-Bianchi A., Vanzulli A., Cresta S., Damian S., Duca M., Ardini E., Li G., Christiansen J., Kowalski K., Johnson A.D., Patel R., Luo D., Chow-Maneval E., Hornby Z., Multani P.S., Shaw A.T., De Braud F.G. Safety and Antitumor Activity of the Multitargeted Pan-Tyrosine Kinase (TRK), ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)
Summary
Острый миелоидный лейкоз, гистиоцитоз, множественная миелома, опухоль из дендритных клеток. Acute myeloid leukemia, histiocytosis, multiple myeloma, a dendritic cell tumor Саркома матки Uterine sarcoma Холангиокарцинома Cholangiocarcinoma Рак поджелудочной железы Pancreas cancer Меланома Melanoma Колоректальный рак Colorectal cancer
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