New Approach to Drug Delivery in Ophthalmological Practice: Development of Composite Ophthalmological Solution for Drug Loading of Soft Contact Lenses

D K Naplekov,A V Bondarev,O O Novikov,A Yu Malyutina,N B Demina,E T Zhilyakova,R A Abramovich

doi:10.33380/2305-2066-2020-9-4-59-64

Abstract

Introduction. This article provides a tentative justification of use of soft contact lenses as a carrier of ophthalmological solutions to eye tissues.Aim. The aim of the research is to develop the composition of the ophthalmic transport system for the treatment of glaucoma. Also, the proposed manufacturing algorithms were proposed for drug loading ophthalmological solutions.Materials and methods. Preparation of sodium hyaluronate solution was carried out based on the methodology described in EP 7.0 [01/2011:1472] (Sodium hyaluronate).Results and discussion. The conducted investigation with the purpose to justify a concentration of sodium hyaluronate helped to determine its concentration that gives the viscosity level as close to the upper limit stated in Russian Pharmacopoeia as possible. Buffer solution was chosen with criteria to use as less components in ophthalmological solution as possible. Also, it was found out that the more components are added to the viscous solution, the more viscosity level is decreased. Thus, initial viscosity of solution containing sodium hyaluronate was 149.59 mm2/s, and after addition of active pharmaceutical substance it dropped down to 88.49 mm2/s and 81.36 mm2/s for model solution number 1 and 2, respectively. After addition of citric acid and disodium hydrophosphate, the viscosity of model solution was found to be 78.11 mm2/s and 75.28 mm2/s for model solution number 1 and 2, respectively.Conclusion. As a result of the studies, two alternative model compositions of an ophthalmic solution for the saturation of soft contact lenses for the treatment of glaucoma were proposed. The choice of active pharmaceutical substances, and excipients has been justified. Technological procedure of preparation of model solution was described and explained, where the most attention was paid on dissolving of sodium hyaluronate in purified water.

Highlights

This article provides a tentative justification of use of soft contact lenses as a carrier of ophthalmological solutions to eye tissues
Since the first mention of soft contact lenses (SCL) in the context of prolonged delivery of active pharmaceutical substances (API) to the eye tissues, a number of methods have been developed to date that allow saturating the lens with pharmacologically active agents
Among the very first and simplest methods for saturating SCL, one can distinguish such as soaking SCL in an ophthalmic solution immediately or several hours before use, instilling eye drops (ED) on the surface of contact lenses already worn on the eyes [1]

Summary

Introduction

This article provides a tentative justification of use of soft contact lenses as a carrier of ophthalmological solutions to eye tissues. As a result of the studies, two alternative model compositions of an ophthalmic solution for the saturation of soft contact lenses for the treatment of glaucoma were proposed. Since the first mention of soft contact lenses (SCL) in the context of prolonged delivery of active pharmaceutical substances (API) to the eye tissues, a number of methods have been developed to date that allow saturating the lens with pharmacologically active agents. Along with the drawbacks of modern methods of saturating contact lenses, there is an advantage – the ability for the patient to independently prepare their SCL for the drug delivery process. The method of soaking contact lenses in an ophthalmic solution does not lose its relevance, and the search for new approaches to its improvement is a promising direction in the development of ophthalmic therapeutic systems [3]

Objectives

Methods

Results