New approach to dextran derivatives containing primary amino functions

Abstract

Dextran derivatives containing primary amino functions were prepared by reacting 4-nitrophenyl carbonate-substituted dextran with the mono-protected diamine N-tritylenediamine (7). Acidic treatment of the resulting dextran N-[2-(N-trityl)aminoethyl]carbamate (8) yields dextran N-(2-aminoethyl)carbamate (5a). Alternatively, aminodextran derivatives were prepared by adding 4-nitrophenyl carbonate-substituted dextran to a large excess of a diamine or a triamine.