Abstract
Hydrogel microwell arrays are new soft substrates for cell cultivation. The microwell morphology has direct influence on the behavior of cells cultured within microwells. But the conventional morphology characterization techniques of hydrogel microwell arrays can not in situ characterize hydrogel microwell arrays in aqueous solution and also not in a reversible way. Using the oxygen dissolved in water as the redox mediator, scanning electrochemical microscopy (SECM) was applied to in situ characterize the morphology of microwell array made of polyethylene glycol dimethacrylate (PEGDMA) hydrogel in aqueous solution. Both the two-dimensional and three-dimensional surface morphology images of PEGDMA microwell arrays were obtained. This work demonstrates that SECM is a new method of in situ characterization of hydrogel microwell arrays in a non-destructive and reversible way with providing three-dimensional surface morphology information.
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