Abstract
Except the application of NMR and mass spectra (MS) to the research of biology, another well known accomplishment of chemical biology is synthetic small-interfering RNA (siRNA) duplexes. Now it is one of the most powerful tools for biological mechanism study by lossof-function assay. Besides successes in research tools, chemical biology has made very prominent progress in the field of diagnostics. No doubt, to develop lower-cost and easier approaches with higher sensitivity and specificity is only direction of chemical biology in future. Scientists have made very significant successes recently, such as nanoparticles for targeting and visualizing tumor tissues [2], DNA synbodies which is new affinity reagent that could offer an easy-to-produce alternative to traditional antibodies [3]. Researchers are also trying to develop new sensors to diagnose HIV at low cost [4].
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