New analysis of seven ant genomes reveals clues to longer life spans associated with sociality.

Abstract

Roux et al. (2014) tried to uncover which genes could be involved in ant-specific adaptations, notably in relation to the evolution of complex social systems and division of labor. Using a combination of state-of-the-art evolutionary tools, the article examines the signatures of positive selection on a phylogeny of seven ants and compares these signatures with those detected in other insect data sets composed of 12 species of flies and 10 species of bees. This design allowed the authors to identify molecular patterns unique to ants, compared with flies and bees. Overall, they identified 24 functional categories of genes that experienced strong positive selection in the ant lineage. Among the significant categories, some were related to nervous system development, behavior, immunity, metabolism, protein translation, and degradation, but similar patterns were observed in flies and bees. Strikingly, they also found ant-specific signals of positive selection on genes with mitochondrial activity that accounted for 11 out of the 24 significant categories. Additional analyses suggested that this could be an important molecular clue that may be responsible for increased life span of queens in the ant lineage—ant queens can live up to 30 years in some species. Mitochondria are cellular power plants whose by-products are thought to be toxic and responsible for aging. “The improvement of mitochondrial activity by positive selection on ant genes might have been an important step toward the evolution of extreme lifespan that is a hallmark of this lineage,” said author Julien Roux.