New β-amino alcohols with a bicyclo[3.3.0]octane scaffold in an asymmetric Henry reaction

Abstract

A new category of β-amino alcohols with a bicyclo[3.3.0]octane scaffold has been synthesized and used in the direct asymmetric nitroaldol reaction (Henry reaction). Up to 74% ee was obtained with the addition of nitromethane to relatively bulky aldehydes.