Abstract
Binding to a variety of natural and synthetic DNAs by cationic water-soluble porphyrins - having three N-methylpyridynium and one amino-acid derivatized phenyl ring as meso substituents - has been investigated. These studies indicate that amino acid porphyrin derivatives are able to intercalate into calf thymus DNA, but not as readily as meso-tetrakis-(N-methyl-4-pyridiniumyl)porphyrin (H 2TMP yP-4). This lowering of affinity for intercalation may be due to the presence of only three positive charges on the porphyrin ion and/or an increased specificity towards specific DNA sequences arising from amino acid linkage.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
