Abstract
The new amidophosphine-phosphinite (AMPP) ligands 4a– g (called tLANOP ligands) derived from the chiral hydroxy amide ( R)- or ( S)-2-hydroxy-3,3, N-trimethylbutyramide have been prepared in 48–83% yield. The crystal structures of the square planar complexes [( SP-4-3)-Pd(( R)-dmphea)(( S)- 4a)]BF 4 and [Rh(( R)- 4a)(COD)]BF 4 have allowed the absolute configurations of the ligands to be assigned. In both complexes the 7-membered chelating ring of 4a has virtually the same twist-boat conformation. With this class of ligands the rhodium catalyzed asymmetric hydrogenation of 4-oxoisophorone enol acetate gave ( S)-phorenol acetate in up to 71% ee. The iridium catalyzed asymmetric hydrogenation of the cyclic iminium salts 16a and 16b afforded after work-up the corresponding cyclic secondary amine ( S)- 17 in up to 86% ee, when bulky groups were present on the phenyl substituents on the two phosphorus atoms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
