Abstract
The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.
Highlights
A considerable number of structurally unique secondary metabolites with biological and pharmacological activities have been isolated from the marine-derived fungi in recent years [1,2].Marine-derived Penicillium and Aspergillus are reported to be the most ubiquitous genera [1]
More than 400 new marine natural products, including half the number of polyketides and a quarter the number of nitrogen compounds have been isolated from marine-derived Penicillium fungi, and 58% of the new products have displayed bioactivities such as anticancer, antibacterial, anti-HIV, and anti-inflammatory properties [4]
As part of our continued searching for bioactive secondary metabolites from sponge-derived fungi [5,6,7], the fungus Penicillium sp
Summary
A considerable number of structurally unique secondary metabolites with biological and pharmacological activities have been isolated from the marine-derived fungi in recent years [1,2]. More than 400 new marine natural products, including half the number of polyketides and a quarter the number of nitrogen compounds have been isolated from marine-derived Penicillium fungi, and 58% of the new products have displayed bioactivities such as anticancer, antibacterial, anti-HIV, and anti-inflammatory properties [4]. As part of our continued searching for bioactive secondary metabolites from sponge-derived fungi [5,6,7], the fungus Penicillium sp. We described the isolation, structure elucidation, and bioactivity evaluation of the twenty-one compounds, as well as the potential biosynthetic pathway of these alkaloids.
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