Abstract
Glioblastoma is the most common malignant glioma in adults, and despite recent advances in standard treatment, the prognosis still remains dismal, with a median survival of 15 months. The incorporation of bevacizumab in the standard treatment of relapsed glioblastoma has been a significant step towards combining targeted agents with chemotherapy, and there is an increasing number of new antiangiogenic agents in various stages of development, that are being tested both in relapsed and newly diagnosed disease, alone or in combination with standard treatment. The relatively favorable toxicity profile for most of them presents an advantage, but several concerns arise regarding their actual efficacy on the clinical level and the most efficient schedule of administration for each of them, as their molecular targets and patterns of action may vary significantly. This may lead to future modifications of the current rational of administering these agents concomitantly with initial chemotherapy or maintenance treatment.
Highlights
Glioblastoma is the most common malignant glioma in adults and, in spite of its relatively low incidence in the general population, it is a disease with extremely high morbidity and mortality
This short paper will focus on bevacizumab and the novel antiangiogenic agents cediranib, cilengitide, sunitinib, sorafenib, vandetanib, aflibercept, ABT-510 XL184, and tandutinib that are currently in various stages of clinical development both on recurrent and untreated glioblastoma
There is clinical evidence of such normalization in patients who were treated with bevacizumab for colorectal cancer or recurrent glioblastoma and in recurrent glioblastoma patients treated with cediranib, a novel pan-vascular endothelial growth factor (VEGF) inhibitor (AZD2171, Recentin) [17,18,19]
Summary
Glioblastoma is the most common malignant glioma in adults and, in spite of its relatively low incidence in the general population, it is a disease with extremely high morbidity and mortality. All patients eventually die of a disease-related complication. The demand for more effective treatment remains imperative and the introduction of new agents in clinical trials continuously produces new data that will hopefully lead to better treatment results in the near future. This short paper will focus on bevacizumab and the novel antiangiogenic agents cediranib, cilengitide, sunitinib, sorafenib, vandetanib, aflibercept, ABT-510 (thrombospondin-1) XL184, and tandutinib that are currently in various stages of clinical development both on recurrent and untreated glioblastoma
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