Abstract

Hypophosphatemic rickets(HR) is a bone mineralization disorder caused by a defect in the renal handling of phosphorus.Depending on the mutant sites,HR is divided into X chromosome-linked HR and autosomal-linked HR.Based on varied mutation points,HR can be further divided into different subtypes.Exploring the genetic linkage(such as phosphate regulating gene with homologies to endopeptidase on X chromosome,fibroblast growth factor,dentin matrix protein and so on) and molecular mechanism of HR,will be helpful in understanding the pathogenesis and treatment of HR. Key words: Hypophosphatemic rickets ; Gene ; Genetic disease

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.