New access to α-substituted ( Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under ‘reduction–oxidative alkylation (R–OA)’ conditions

Abstract

( Z)-Fluoroalkene dipeptide isosteres serve as potential dipeptide mimetics. The present paper reports a new access to α-substituted ( Z)-fluoroalkene isosteres utilizing an organocopper-mediated ‘reduction–oxidative alkylation (R–OA)’ reaction.