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Abstract
New 2′-deoxyuridine derivatives containing long-chain hydrophilic substituents or hydrophilic groups at the 5 position of uracil were synthesized. 5-[4-(2-Carboxyethylcarbonylamino)-butyloxymethyl]-2′-deoxyuridine completely inhibits the growth of Mycobacterium tuberculosis at a concentration of 50 μg mL−1. However, oligo(ethylene glycol) derivatives do not exhibit activity even at high concentrations.
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