Abstract
This paper reports the synthesis of a series of 5 H-1,2,4-triazino[5,6- b]indole 3 and 4, and aminoindole 12–23, derivatives, obtained from isatin 1 and from oxoindole 5, respectively. All the new compounds were studied as antihypertensive agents in spontaneously hypertensive rats (SHR), and as inhibitors of platelet aggregation in guinea pig whole blood, induced by arachidonic acid (AA), adenosin-5′-diphosphate (ADP) or collagen. The most active antiaggregating compounds were also studied as thromboxane A 2 synthetase inhibitors.
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