New 4,4′-methylenedianiline monobactame compounds: Synthesis, antioxidant and antimicrobial activities evaluation

Abstract

Reactive oxygen species (ROS) in the form of free radicals (superoxide, singlet oxygen, hydroxyl radical) and neutral molecules (hydrogen peroxide) play an significant role in the development of many serious diseases. If they produced in high level they can produce damage to lipids, proteins, and DNA. Antioxidants are defined as scaffolds that suspend, prevent or eliminate oxidative damage to target vital molecules when introduced in low concentrations. Infectious diseases are among the chief causes of death worldwide, and antimicrobial resistance has been regularly reported globally. These complications necessitate the emerge of a new antioxidant and antimicrobial agents that are effective, safe, and selective. This study examines the antioxidant and the antimicrobial activity for new synthesized compounds with two monobactame moiety derived from 4,4'- methylenedianiline. The chemical structures for the new synthesized compounds were distinguished the physical and spectral data. The antioxidant activity of these compounds was evaluated by testing their free radical scavenging activity of DPPH (1,1-diphenyl-2-picryl-hydrazyl) and H2O2, also the antimicrobial activity of the synthesized compounds was evaluated via measuring the inhibition zones in the disk diffusion method. The tested synthesized compounds show varied antioxidant and antimicrobial activities. The hydroxyl and the amide moiety in any organic compound could possess potent antioxidant activities. The aliphatic and aromatic chlorine atoms possess potent antibacterial activities, and these activities increases as the number of the chlorine substitutions increased too. The ether group in any organic compound could represent a potent antifungal activity.