New 2‐Phenylquinoline‐Based Bis‐Methoxymethyl‐1,2,3‐Triazoles as Potential Antimicrobial Agents: Synthesis and Molecular Docking Studies against COVID‐19

Abstract

AbstractSynthesis of novel 2‐phenylqinoline conjugated bis‐triazole analogues 8(a–n) demonstrated by a series of reactions concerning Vilsmeier‐Haack reaction, Suzuki‐Miyaura cross coupling, reduction of carbonyl groups, and click reaction. The structure of final compounds predicted based on IR, 1H, 13C NMR and Mass spectral data analysis. The title compounds were screened for their in vitro antimicrobial activities against two‐gram positive (S. aureus and S. pyogens) and two‐gram negative (P. aeruginosa and E. coli) bacteria, and two fungal strains (S. rolfs and F. ricini) by employing Amoxicillin and Bavistin as standard drugs, respectively. The compound containing 3‐chlorophenyl, 4‐(trifluoromethyl)phenyl, 3,4‐dimethylphenyl and 3‐fluoro‐4‐chlorophenyl residues, indicated promising antibacterial activity and the best antifungal activity was reported for compounds containing 3‐chlorophenyl, 4‐methoxyphenyl and 4‐(trifluoromethyl)phenyl residues. Further, Insilco screening of these compounds against COVID‐19 main protease of corona virus had displayed good docking scores and binding interactions in its active site pocket.