Abstract
Eight new triterpenoids, including sinocalycanchinensins A–E ( 1– 5) with a 3,4- seco-29- nor-cycloartane skeleton, sinocalycanchinensin F ( 6) possessing a novel 2,3- seco-29- nor-cycloartane skeleton, and 29- nor-cycloartanes, sinocalycanchinensins G and H ( 7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.
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