Abstract
Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-24(S)-methylcholesta-6,9(11),22-trien-3β-ol (5), were isolated from an octocoral Dendronephthya sp. The structures of steroids 1 and 2 were elucidated by using spectroscopic methods and steroid 1 was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
Highlights
Marine invertebrates, octocorals have been well recognized as a rich source of interesting steroid metabolites [1]
The results indicated that dendronesterone D (1) showed the most potent suppressive effects on iNOS
The results suggested that the anti- inflammatory activities of steroids 1–3 were mainly reliant on the functional group at C-11
Summary
Octocorals have been well recognized as a rich source of interesting steroid metabolites [1]. In continuation of research into new substances from marine invertebrates collected off the waters of Taiwan, a series of steroid derivatives have been isolated from the octocorals belonging to the genus Dendronephthya Resulted in the isolation of two new marine steroids, dendronesterones. [5], and two cytotoxic metabolites, 5α,8α-epidioxy-24(S)-methylcholesta-6,22-dien-3β-ol (4) and. 2 of methylcholesta-6,22-dien-3β-ol (4) and 5α,8α-epidioxy-24(S)-methylcholesta- 6,9(11),22-trien-3β-ol (5). Wecylindrus reported[7], isolation and structural determination of steroids isolation and structural determination of steroids. The ability of 1–5 to reduce the expression of the pro-inflammatory iNOS (inducible nitric oxide pro-inflammatory iNOS (inducible nitric oxide synthase). Proteins synthase) and COX-2 (cyclooxygenase-2) proteins in LPS (lipopolysaccharides)-stimulatedin.
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