Abstract
Our research team has synthesized new compounds involving the reaction of α‐(N)‐heterocyclic substrates, including methyl‐imidazole‐2‐carboxaldehyde, with several commercially available thiosemicarbazides (TSC's) to form many new α‐(N)‐heterocyclic thiosemicarbazone compounds, which act as tridentate monoanionic ligands with Cu2+ and Pd2+. These ligands were synthesized in the lab, recrystallized, and analyzed via ¹H NMR and ¹³C NMR spectroscopy using ¹H detected ¹³C and 15N Heteronuclear Single Quantum Coherence (HSQC) and Heteronuclear Multiple‐Bond Correlation (HMBC) experiments. The NMR spectra show evidence for the proposed structures for the ligands. We have performed anti‐proliferative MIC (minimum inhibitory concentration) studies using seven different microbes with the ligands and the metal complexes in order to determine the anti‐microbial properties of each TSC compound synthesized, and have found that the Cu and Pd metal complexes of these ligands have significant anti‐proliferative activities. We relate these anti‐microbial properties to activity against Topoisomerase IIa.
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